3-O Sulfated Heparan Sulfate (G2) Peptide Ligand Impairs the Infectivity of <i>Chlamydia muridarum</i>

3-O Sulfated Heparan Sulfate (G2) Peptide Ligand Impairs the Infectivity of <i>Chlamydia muridarum</i>

<b>Background:</b> Heparan sulfate (HS) is widely implicated as a receptor for <i>Chlamydia</i> cell attachment and infectivity. However, the enzymatic modification of HS modified by the 3-O sulfotransferase-3 (3-OST-3) enzyme in chlamydial cell entry remains unknown. <b&g...

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Bibliographic Details
Main Authors: Weronika Hanusiak, Purva Khodke, Jocelyn Mayen, Kennedy Van, Ira Sigar, Balbina J. Plotkin, Amber Kaminski, James Elste, Bajarang Vasant Kumbhar, Vaibhav Tiwari
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomolecules
Subjects:
<i>Chlamydia</i>
infectivity
intracellular
computational modeling
molecular dynamics
Online Access:https://www.mdpi.com/2218-273X/15/7/999
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