EV-A71 invades the central nervous system and affects the blood-brain barrier in a tree shrew model

EV-A71 invades the central nervous system and affects the blood-brain barrier in a tree shrew model

IntroductionThe enterovirus A71 (EV-A71)-caused central nerve system (CNS) damage seriously endangers the health of infants and young children, but the underlying mechanisms by which EV-A71 crosses the blood-brain barrier (BBB) are still largely unknown. This study developed a tree shrew (Tupaia bel...

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Main Authors: Wen-Guang Wang, Xuan Wang, Na Li, De-Xuan Kuang, Pin-Fen Tong, Cai-Xia Lu, Yuan-Yuan Han, Xiao-Mei Sun, Jie-Jie Dai, Long-Ding Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
enterovirus A71
tree shrew
infection
neurotropism
blood brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583768/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1583768/full

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