The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions

The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions

Abstract Background Homo- and heteromerization of G protein-coupled receptors (GPCRs) plays an important role in the regulation of receptor functions. Recently, we demonstrated an interaction between the serotonin receptor 7 (5-HT7R), a class A GPCR, and the cell adhesion molecule CD44. However, the...

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Main Authors: Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A. Gaitonde, Michel Bouvier, Michael C. Wehr, Josephine Labus, Evgeni Ponimaskin
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
G protein-coupled receptor (GPCR)
Receptor oligomerization
Serotonin receptor 7 (5-HT7R)
Hyaluronan receptor CD44
Fluorescence Resonance Energy Transfer (FRET)
Bioluminescence Resonance Energy Transfer (BRET)
Online Access:https://doi.org/10.1186/s12964-024-01931-0
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https://doi.org/10.1186/s12964-024-01931-0

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