A protein language model for exploring viral fitness landscapes

A protein language model for exploring viral fitness landscapes

Abstract Successively emerging SARS-CoV-2 variants lead to repeated epidemic surges through escalated fitness (i.e., relative effective reproduction number between variants). Modeling the genotype–fitness relationship enables us to pinpoint the mutations boosting viral fitness and flag high-risk var...

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Main Authors: Jumpei Ito, Adam Strange, Wei Liu, Gustav Joas, Spyros Lytras, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Kei Sato
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59422-w
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https://doi.org/10.1038/s41467-025-59422-w

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