SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1

SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1

Abstract Folliculogenesis is a crucial process for production functional female gametes in mammals. The imbalance of apoptosis and proliferation of ovarian granulosa cells has been identified as an important cause for abnormal folliculogenesis. Sex-determining region Y-box protein 3 (SOX3), belonged...

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Bibliographic Details
Main Authors: Rui Cai, Cong Li, Wenhui Shi, Fenfen Xie, Mengmeng Fan, Hao Zhang, Zhuang Liu, Yuanhua Chen, Qiang Hong
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
Folliculogenesis
SOX3
Proliferation
Apoptosis
SPP1
PI3K/AKT pathway
Online Access:https://doi.org/10.1007/s00018-025-05797-4
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https://doi.org/10.1007/s00018-025-05797-4

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