Fast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli

Fast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli

Abstract Microbial bioproduction using one-carbon (C1) feedstocks has the potential to decarbonize the manufacturing of materials, fuels, and chemicals. Formate is a promising C1 feedstock, and the realization of industrial, formatotrophic platform organisms is a key goal for C1-based bioproduction....

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Main Authors: Aidan E. Cowan, Mason Hillers, Vittorio Rainaldi, Florent Collas, Hemant Choudhary, Basem S. Zakaria, Gregory G. Bieberach, David N. Carruthers, Maxwell Grabovac, Jennifer W. Gin, Bridgie Cawthon, Yan Chen, Emine Akyuz Turumtay, Edward E. K. Baidoo, Christopher J. Petzold, Adam M. Feist, Sara Tejedor-Sanz, Frank Kensy, Blake A. Simmons, Jay D. Keasling, Nico J. Claassens
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61001-y
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https://doi.org/10.1038/s41467-025-61001-y

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