Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies

Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies

Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most of the causal mechanisms of lipids remain unkno...

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Main Authors: Daiwei Zhang, Boran Gao, Qidi Feng, Ani Manichaikul, Gina M. Peloso, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Francois Aguet, Kristin G. Ardlie, Thomas W. Blackwell, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Laura J. Scott, Xiang Zhou, Seunggeun Lee
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:HGG Advances
Subjects:
blood lipids
Multi-omics
proteome-wide association studies
transcriptome-wide association studies
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247724001234
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