Comprehensive genomic dependency landscape of a human colon cancer organoid

Comprehensive genomic dependency landscape of a human colon cancer organoid

Abstract Identifying genetic dependencies in human colon cancer could help identify effective treatment strategies. Genome-wide CRISPR-Cas9 dropout screens have the potential to reveal genetic dependencies, some of which could be exploited as therapeutic targets using existing drugs. In this study,...

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Main Authors: Sana Khalili, Atefeh Mohseninia, Changlong Liu, Carolyn E. Banister, Paige Heine, Minou Khazan, Sidney E. Morrison, Prashanth Gokare, Glenn S. Cowley, Barbara A. Weir, David Pocalyko, Kurtis E. Bachman, Phillip J. Buckhaults
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07822-5
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https://doi.org/10.1038/s42003-025-07822-5

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