Unraveling the metabolic activities of bioactive compounds on cellular models of hepatosteatosis and adipogenesis through docking analysis with PPARs

Unraveling the metabolic activities of bioactive compounds on cellular models of hepatosteatosis and adipogenesis through docking analysis with PPARs

Abstract Obesity is associated with fatty liver disease. Available therapies show modest efficacy, and nutraceuticals with good effectiveness and safety are largely investigated. We focused on five natural compounds, three plant phenolic compounds (carvacrol, rosmarinic acid, silybin), and two thyro...

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Bibliographic Details
Main Authors: Farah Diab, Hawraa Zbeeb, Lama Zeaiter, Francesca Baldini, Aldo Pagano, Velia Minicozzi, Laura Vergani
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Natural products
Hepatosteatosis
Adipogenesis
Metabolic activities
Nuclear receptors
Molecular Docking
Online Access:https://doi.org/10.1038/s41598-024-78374-7
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https://doi.org/10.1038/s41598-024-78374-7

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