Exosomal FOXL1 from bone marrow mesenchymal stem cells activates the METTL3/ATXN2L pathway to ameliorate high glucose-induced human retinal microvascular endothelial cell injury

Exosomal FOXL1 from bone marrow mesenchymal stem cells activates the METTL3/ATXN2L pathway to ameliorate high glucose-induced human retinal microvascular endothelial cell injury

Abstract Background Bone marrow mesenchymal stem cells (BMSCs) and their secreted exosomes have been shown to possess therapeutic potential in various diseases, including diabetic retinopathy (DR). Retinal microvascular endothelial cell (RMEC) injury is a key factor in DR, and understanding the unde...

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Bibliographic Details
Main Authors: Chao Niu, Daoquan Dong, Longjiang Cui, Yingli Dong, Wei Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Diabetic retinopathy
Mesenchymal stem cells
Exosomes
FOXL1
METTL3
ATXN2L
Online Access:https://doi.org/10.1186/s13098-025-01804-7
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https://doi.org/10.1186/s13098-025-01804-7

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