Mechanisms of astrocyte aging in reactivity and disease
Abstract Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organisms age. Here, we examine the transcriptional, cell biology, and functional differences in a...
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| Language: | English |
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BMC
2025-02-01
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| Series: | Molecular Neurodegeneration |
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| Online Access: | https://doi.org/10.1186/s13024-025-00810-7 |
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| author | Holly K. Gildea Shane A. Liddelow |
| author_facet | Holly K. Gildea Shane A. Liddelow |
| author_sort | Holly K. Gildea |
| collection | DOAJ |
| description | Abstract Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organisms age. Here, we examine the transcriptional, cell biology, and functional differences in astrocytes across normal aging. Astrocytes at baseline are heterogenous, responsive to their environments, and critical regulators of brain microenvironments and neuronal function. With increasing age, astrocytes adopt different immune-related and senescence-associated states, which relate to organelle dysfunction and loss of homeostasis maintenance, both cell autonomously and non-cell autonomously. These perturbed states are increasingly associated with age-related dysfunction and the onset of neurodegeneration, suggesting that astrocyte aging is a compelling target for future manipulation in the prevention of disease. |
| format | Article |
| id | doaj-art-d2c78e9990784ef0bc31e795a83deda7 |
| institution | OA Journals |
| issn | 1750-1326 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj-art-d2c78e9990784ef0bc31e795a83deda72025-08-20T02:15:07ZengBMCMolecular Neurodegeneration1750-13262025-02-0120111410.1186/s13024-025-00810-7Mechanisms of astrocyte aging in reactivity and diseaseHolly K. Gildea0Shane A. Liddelow1Institute for Translational Neuroscience, NYU Grossman School of MedicineInstitute for Translational Neuroscience, NYU Grossman School of MedicineAbstract Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organisms age. Here, we examine the transcriptional, cell biology, and functional differences in astrocytes across normal aging. Astrocytes at baseline are heterogenous, responsive to their environments, and critical regulators of brain microenvironments and neuronal function. With increasing age, astrocytes adopt different immune-related and senescence-associated states, which relate to organelle dysfunction and loss of homeostasis maintenance, both cell autonomously and non-cell autonomously. These perturbed states are increasingly associated with age-related dysfunction and the onset of neurodegeneration, suggesting that astrocyte aging is a compelling target for future manipulation in the prevention of disease.https://doi.org/10.1186/s13024-025-00810-7AgingAstrocyteGliaAstrocyte reactivityNeurodegenerative diseaseLipid droplets |
| spellingShingle | Holly K. Gildea Shane A. Liddelow Mechanisms of astrocyte aging in reactivity and disease Molecular Neurodegeneration Aging Astrocyte Glia Astrocyte reactivity Neurodegenerative disease Lipid droplets |
| title | Mechanisms of astrocyte aging in reactivity and disease |
| title_full | Mechanisms of astrocyte aging in reactivity and disease |
| title_fullStr | Mechanisms of astrocyte aging in reactivity and disease |
| title_full_unstemmed | Mechanisms of astrocyte aging in reactivity and disease |
| title_short | Mechanisms of astrocyte aging in reactivity and disease |
| title_sort | mechanisms of astrocyte aging in reactivity and disease |
| topic | Aging Astrocyte Glia Astrocyte reactivity Neurodegenerative disease Lipid droplets |
| url | https://doi.org/10.1186/s13024-025-00810-7 |
| work_keys_str_mv | AT hollykgildea mechanismsofastrocyteaginginreactivityanddisease AT shanealiddelow mechanismsofastrocyteaginginreactivityanddisease |