Mechanisms of astrocyte aging in reactivity and disease

Abstract Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organisms age. Here, we examine the transcriptional, cell biology, and functional differences in a...

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Bibliographic Details
Main Authors: Holly K. Gildea, Shane A. Liddelow
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Neurodegeneration
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Online Access:https://doi.org/10.1186/s13024-025-00810-7
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