Computational insights into the inhibitory effects of PFAS 14 on colorectal cancer targeting GSTA1 through competitive binding

Computational insights into the inhibitory effects of PFAS 14 on colorectal cancer targeting GSTA1 through competitive binding

This study employed computational biology approaches to investigate the interactions between per- and polyfluoroalkyl substances (PFAS) and key colorectal cancer (CRC) proteins. The results indicate that PFAS may influence CRC progression by modulating multiple proteins, particularly glutathione S-t...

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Bibliographic Details
Main Authors: Jinxiao Li, Yanran Wu, Pian Ye, Dongmei Zuo, Shuangjiao Deng, Ran Pang, Huarong Li
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PFAS
Colorectal cancer
Survival analysis
Computational biology
GSTA1
Competitive binding
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325002611
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