The crucial role of SPP1 in osteoporosis, osteoarthritis, and cancer

Osteopontin (OPN), also known as secreted phosphoprotein 1(SPP1), is a highly glycosylated and phosphorylated acidic protein, which is a multifunctional glycoprotein expressed in numerous cell types. SPP1 is involved in the attachment of osteoclasts to mineralized bone matrix, inflammatory reaction,...

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Bibliographic Details
Main Authors: Yaru Qu, Shuixian Li, Huiyuan Luo, Junnan Li, Tong Wang, Xiuzhen Han
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Pharmaceutical Science Advances
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2773216925000121
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