Anlotinib inhibits c-MET and ITGA2 in the treatment of anaplastic thyroid carcinoma

Anlotinib inhibits c-MET and ITGA2 in the treatment of anaplastic thyroid carcinoma

Abstract Objective This study explored the therapeutic effects of anlotinib in anaplastic thyroid carcinoma (ATC) models and the underlying molecular mechanisms. Methods Human C643 and CAL-62 anaplastic thyroid carcinoma cell lines were cultured in vitro and treated with anlotinib. The effects of an...

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Bibliographic Details
Main Authors: Shunshun Zhao, Mingyao Meng, Ruochuan Cheng, Min Zhang, Chuanyuan Liu, Qiuyu Meng, Tingting Yang, Haohan Huang, Bin Liu, Xiaodan Wang, Yanjun Su
Format: Article
Language:English
Published: BMC 2025-04-01
Series:World Journal of Surgical Oncology
Subjects:
Anlotinib
Anaplastic thyroid carcinoma
c-MET
ITGA2
COL5A1
Online Access:https://doi.org/10.1186/s12957-025-03810-5
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https://doi.org/10.1186/s12957-025-03810-5

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