N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1

N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1

Abstract Background Age-related kidney impairment, characterized by tubular epithelial cell senescence and renal fibrosis, poses a significant global public health threat. Although N6-methyladenosine (m6A) methylation is implicated in various pathological processes, its regulatory mechanism in kidne...

Full description

Saved in:

Bibliographic Details
Main Authors:	Li Xu, Shuo Chen, Qiuling Fan, Yonghong Zhu, Hang Mei, Jiao Wang, Hongyuan Yu, Ying Chen, Fan Liu
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Series:	BMC Biology
Subjects:	N6-methyladenosine (m6A) methylation GLIS1 Kidney aging Fatty acid oxidation (FAO) Glycolysis
Online Access:	https://doi.org/10.1186/s12915-024-02100-y
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Problem ochrony gatunku popielicy (Glis glis L.) w Polsce
by: Magdalena Klaudia Terlecka
Published: (2010-06-01)

GLIS3: A novel transcriptional regulator of mitochondrial functions and metabolic reprogramming in postnatal kidney and polycystic kidney disease
by: Justin B. Collier, et al.
Published: (2024-12-01)

Emerging roles of N6-methyladenosine in arsenic-induced toxicity
by: Rongxian Li, et al.
Published: (2024-11-01)

N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility
by: Yalun He, et al.
Published: (2024-12-01)

Identification and Characterisation of Potential Targets for N6-methyladenosine (m6A) Modification during Intervertebral Disc Degeneration
by: Jianlin Shen, et al.
Published: (2024-11-01)

Research advances on the mechanism of N6-methyladenosine modification in diabetic kidney disease
by: Jian-yu Chen, et al.
Published: (2024-12-01)

The role of N6-methyladenosine modification in tumor angiogenesis
by: Lifei Qin, et al.
Published: (2024-12-01)

N6-methyladenosine RNA methylation, a new hallmark of metabolic reprogramming in the immune microenvironment
by: Xiaoyue Li, et al.
Published: (2024-12-01)

The Correlation Analysis Between m6A Methylation Modification and Ferroptosis Induced by Cigarette Smoke in Human Bronchial Epithelium
by: Xiaomei Duan, et al.
Published: (2024-12-01)

IGF2BP1 accelerates the aerobic glycolysis to boost its immune escape in hepatocellular carcinoma microenvironment
by: Xuxing Ye, et al.
Published: (2024-11-01)

N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases
by: Xiangrong Cui, et al.
Published: (2024-12-01)

When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?
by: Wenjing Wang, et al.
Published: (2024-12-01)

Regulation of Shade Avoidance Under Low‐Blue‐Light by MTA in Soybean
by: Liya Zhang, et al.
Published: (2025-02-01)

New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy
by: Mengran Li, et al.
Published: (2025-01-01)

Identification of key differentially methylated genes regulating muscle development in chickens: insights from Jingyuan breed
by: Tong Zhang, et al.
Published: (2024-12-01)

N6-methyladenosine modification of THBS1 induced by affluent WTAP promotes Graves’ ophthalmopathy progression through glycolysis to affect Th17/Treg balance
by: Lin-na Li, et al.
Published: (2025-12-01)

Genome-wide identification of cell type-specific susceptibility genes for Juvenile dermatomyositis through the analysis of N6-methyladenosine-associated SNPs
by: Huan Zhang, et al.
Published: (2024-12-01)

N6‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion
by: Wei Wang, et al.
Published: (2023-02-01)

IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A‐Mediated NLRP3 Inflammasome
by: Wu Jingrui, et al.
Published: (2025-01-01)

Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers
by: Weiping Ji, et al.
Published: (2025-03-01)

Biosynthesis inhibition of miR-142-5p in a N 6-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling
by: Jinshi Li, et al.
Published: (2025-01-01)

m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus
by: Lijiu Zhao, et al.
Published: (2025-01-01)

Nanopore direct RNA sequencing reveals N 6-methyladenosine and polyadenylation landscapes on long non-coding RNAs in Arabidopsis thaliana
by: Qiaoxia Liang, et al.
Published: (2024-11-01)

Interpretable deep cross networks unveiled common signatures of dysregulated epitranscriptomes across 12 cancer types
by: Rong Xia, et al.
Published: (2024-12-01)

RNA N6‐Methyladenosine‐Binding Protein YTHDFs Redundantly Attenuate Cancer Immunity by Downregulating IFN‐γ Signaling in Gastric Cancer
by: Dongjun Jang, et al.
Published: (2025-01-01)

Decoding the prognostic landscape of LUAD: the interplay between N6-methyladenosine modification and immune microenvironment
by: Quan Chen, et al.
Published: (2024-12-01)

FTO suppresses cardiac fibrosis after myocardial infarction via m6A-mediated epigenetic modification of EPRS
by: Jian Wang, et al.
Published: (2024-11-01)

The mRNA N<sup>6</sup>-Methyladenosine Response to Dehydration in <i>Xenopus laevis</i>
by: Saif Rehman, et al.
Published: (2024-11-01)

Expression patterns and clinical value of key m6A RNA modification regulators in smoking patients with coronary artery disease
by: Huanwei Zhuang, et al.
Published: (2024-12-01)

Epigenetic Activation of the CMTM6‐IGF2BP1‐EP300 Positive Feedback Loop Drives Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma
by: Ying‐Qin Zhu, et al.
Published: (2024-12-01)

m6A-Methylated NUTM2B-AS1 Promotes Hepatocellular Carcinoma Stemness Feature via Epigenetically Activating BMPR1A Transcription
by: Li W, et al.
Published: (2024-12-01)

N6‐Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression
by: Yalan Rui, et al.
Published: (2025-01-01)

Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy
by: Lu Liu, et al.
Published: (2024-12-01)

N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis
by: Kao-Jung Chang, et al.
Published: (2024-11-01)

m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus
by: Yi Jia, et al.
Published: (2024-11-01)

m6A modification of RNA in cervical cancer: role and clinical perspectives
by: Yajuan Gao, et al.
Published: (2024-12-01)

PSATF-6mA: an integrated learning fusion feature-encoded DNA-6 mA methylcytosine modification site recognition model based on attentional mechanisms
by: Yanmei Kang, et al.
Published: (2024-11-01)

METTL14-mediated m6A modification upregulated SOCS3 expression alleviates thyroid cancer progression by regulating the JAK2/STAT3 pathway
by: Ming Zhou, et al.
Published: (2024-12-01)

Arsenic inducible islet β-cell dysfunction and ferroptosis through m6A-YTHDF2-dependent CHAC1 enhancement
by: Tianming Qiu, et al.
Published: (2025-01-01)

RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts
by: Yingying Zou, et al.
Published: (2024-11-01)