In vivo production of CAR T cell: Opportunities and challenges

In vivo production of CAR T cell: Opportunities and challenges

Chimeric antigen receptor T (CAR T) cell therapy has achieved remarkable efficacy for patients with hematological malignancies. However, in vitro viral vector-mediated production of CAR T cells is time-consuming and expensive and impairs T cell function. On one hand, an elaborate manufacturing proce...

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Bibliographic Details
Main Authors: Zhiqiang Song, Yi Zhou, Binbin Wang, Yuke Geng, Gusheng Tang, Yang Wang, Jianmin Yang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Genes and Diseases
Subjects:
Chimeric antigen receptor T cell
Hematological malignancies
In vivo production
Nonviral vector
Viral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225001011
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