Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development

Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development

The observation that the risk of developing Alzheimer's disease is reduced in individuals with high premorbid cognitive functioning, higher educational attainment, and occupational status has led to the ‘cognitive reserve’ hypothesis. This hypothesis suggests that individuals with greater cogni...

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Main Authors: Piotr Jaholkowski, Shahram Bahrami, Vera Fominykh, Guy F.L. Hindley, Markos Tesfaye, Pravesh Parekh, Nadine Parker, Tahir T. Filiz, Kaja Nordengen, Espen Hagen, Elise Koch, Nora R. Bakken, Evgeniia Frei, Viktoria Birkenæs, Zillur Rahman, Oleksandr Frei, Jan Haavik, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Alexey A. Shadrin, Ole A. Andreassen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Cognition
Educational attainment
Genetics/genomics
Neurodevelopment
MiXeR
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003528
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