Carbon ion stimulation therapy reverses iron deposits and microglia driven neuroinflammation and induces cognitive improvement in an Alzheimer’s disease mouse model

Carbon ion stimulation therapy reverses iron deposits and microglia driven neuroinflammation and induces cognitive improvement in an Alzheimer’s disease mouse model

Abstract Insoluble iron deposits often exist as iron oxide nanoparticles in protein aggregates, impaired ferritin, or activated microglia and have been implicated as major causes of neuroinflammation in Alzheimer’s disease. However, no crucial evidence has been reported to support the therapeutic ef...

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Bibliographic Details
Main Authors: Won-Seok Lee, Toshiaki Kokubo, Younshick Choi, Tsuyoshi Hamano, Alexander Zaboronok, Takaaki Ishikawa, Oh-Dae Kwon, EunHo Kim, Jong-Ki Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Iron deposition
Carbon beam transmission
Iron oxide nanoparticles
Microglial polarization
Neuroinflammation
Online Access:https://doi.org/10.1038/s41598-025-91689-3
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https://doi.org/10.1038/s41598-025-91689-3

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