Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor

Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor

IntroductionThe major histocompatibility complex class I-related gene A (MICA), is a highly polymorphic gene, serve as a crucial role in immune regulator through its interaction with the NKG2D receptor on natural killer (NK) cells. These polymorphisms may influence immune responses, disease suscepti...

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Bibliographic Details
Main Authors: Qizhi Luo, Xiangli Yin, Quan Zhu, Weiguang Luo, Rongjiao Liu, Leiyan Wei, Yizhou Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
MICA polymorphisms
NKG2D receptor
NK cell
binding affinity
immune regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563872/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563872/full

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