Intradiscal Mesenchymal Stromal Cell Therapy for the Treatment of Low Back Pain Due to Moderate‐to‐Advanced Multilevel Disc Degeneration: A Preliminary Report of a Double‐Blind, Phase IIB Randomized Clinical Trial (DREAM Study)

Intradiscal Mesenchymal Stromal Cell Therapy for the Treatment of Low Back Pain Due to Moderate‐to‐Advanced Multilevel Disc Degeneration: A Preliminary Report of a Double‐Blind, Phase IIB Randomized Clinical Trial (DREAM Study)

ABSTRACT Background Low back pain (LBP) is a leading cause of disability worldwide, often associated with intervertebral disc degeneration (IDD). Mesenchymal stromal cells (MSCs) have emerged as a promising regenerative therapy for IDD due to their ability to promote tissue repair. This phase IIB ra...

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Main Authors: Gianluca Vadalà, Fabrizio Russo, Cristiana Lavazza, Giorgia Petrucci, Luca Ambrosio, Silvia Budelli, Elisa Montelatici, Giuseppina Di Giacomo, Claudia Cicione, Veronica Tilotta, Giuseppe Francesco Papalia, Matteo Pileri, Amalia Bruno, Salvatore La Rosa, Emilio Carrino, Eliodoro Faiella, Massimiliano Carassiti, Lorenza Lazzari, Rocco Papalia, Vincenzo Denaro
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:JOR Spine
Subjects:
clinical trial
intervertebral disc degeneration
intervertebral disc regeneration
low back pain
RCT
regenerative medicine
Online Access:https://doi.org/10.1002/jsp2.70086
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https://doi.org/10.1002/jsp2.70086

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