Development of thin-film micro-outlets for spatially constraining local PO2 perturbations to capillaries in vivo

ObjectiveTo develop and validate thin-film micro-outlet devices to study microvascular blood flow responses to localized changes in skeletal muscle oxygen concentration ([O2]).Methods30 male Sprague-Dawley rats (159–194 g) were anesthetized and instrumented to maintain cardiovascular state. The exte...

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Bibliographic Details
Main Authors: Meghan E. Kiley, Richard J. Sové, Reilly H. Smith, Brenda N. Wells, Gaylene M. Russell McEvoy, Graham M. Fraser
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Physiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1575776/full
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