The presence of substrate warrants oxygen access tunnels toward the catalytic site of lipoxygenases

The presence of substrate warrants oxygen access tunnels toward the catalytic site of lipoxygenases

Ferroptosis is a regulated form of cell death driven by lipid peroxidation, with 15-lipoxygenase (15LOX) enzyme playing a critical role in catalyzing the oxygenation of polyunsaturated fatty acid-containing phospholipids, such as 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine (SAPE), to...

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Bibliographic Details
Main Authors: Thiliban Manivarma, Wieslaw Nowak, Yulia Y. Tyurina, Vladimir A. Tyurin, Hülya Bayir, Valerian E. Kagan, Karolina Mikulska-Ruminska
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
Ferroptosis
15-Lipoxygenase
PEBP1
Ligand transport
molecular dynamics
Phospholipids
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001491
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