Comparison of enzymatic and bisulfite conversion of circulating cell-free tumor DNA for DNA methylation analyses

Comparison of enzymatic and bisulfite conversion of circulating cell-free tumor DNA for DNA methylation analyses

Abstract Background Detection of DNA methylation biomarkers in circulating cell-free DNA (cfDNA) has great clinical potential for cancer management, but there is a high need for method optimization and standardization. Bisulfite conversion of DNA is the gold-standard pre-treatment method for DNA met...

Full description

Saved in:
Bibliographic Details
Main Authors: Stine H. Kresse, Evy Marie Thorkildsen, Sara Brandt-Winge, Heidi Pharo, Hege Marie Vedeld, Guro E. Lind
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Clinical Epigenetics
Subjects:
Enzymatic conversion
Enzymatic Methyl-seq
Bisulfite conversion
DNA methylation
Liquid biopsy
Plasma
Online Access:https://doi.org/10.1186/s13148-025-01901-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13148-025-01901-4

Similar Items