Synthesis and <i>In Vitro</i> Anticancer Activity of Pyrrolidone Derivatives Bearing 3,4,5-Trimethoxyphenyl Moiety as a Promising Anticancer Scaffold

Synthesis and <i>In Vitro</i> Anticancer Activity of Pyrrolidone Derivatives Bearing 3,4,5-Trimethoxyphenyl Moiety as a Promising Anticancer Scaffold

A series of 5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carboxylic acid derivatives–hydrazones, <i>N</i>-ethylhydrazones, pyrrole, pyrazole, oxadiazole, and triazole were synthesized and evaluated for their anticancer activity using human A549 pulmonary epithelial cells (ATCC CCl-185)....

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Main Authors: Povilas Kavaliauskas, Birutė Sapijanskaitė-Banevič, Birutė Grybaitė, Eglė Mickevičiūtė, Kazimieras Anusevičius, Andrew Garcia, Ethan Naing, Rūta Petraitienė, Vidmantas Petraitis, Ramunė Grigalevičiūtė, Vytautas Mickevičius
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Applied Sciences
Subjects:
3,4,5-trimethoxyphenyl scaffold
hydrazides
hydrazones
azoles
anticancer activity
Online Access:https://www.mdpi.com/2076-3417/14/24/11784
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