Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP

Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP

Abstract Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a significant global public health concern. Despite its profound health impact in both endemic and non-endemic areas, no vaccine is available, and the existing therapies are outdated, producing severe side effects....

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Main Authors: Sagar Batra, Francisco Olmo, Timothy J. Ragan, Merve Kaplan, Valeria Calvaresi, Asger Meldgaard Frank, Claudia Lancey, Mahya Assadipapari, Cuifeng Ying, Weston B. Struwe, Emma L. Hesketh, John M. Kelly, Lea Barfod, Ivan Campeotto
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62068-3
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https://doi.org/10.1038/s41467-025-62068-3

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