Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury

Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury

ObjectiveSepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication in septic patients. This study combines network pharmacology with in vitro and in vivo experiments to preliminarily investigate the protective effect of chrysophanol (CHR) on SA-AKI and its mechanism, aimin...

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Bibliographic Details
Main Authors: Xuan Gou, Wei Zhang, Lele Wang, Caixia Tan, Hong Wei, Xinmin Wang, Le Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
chrysophanol
sepsis
acute kidney injury
macrophage polarization
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1641068/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1641068/full

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