Hyperoxia exposure induces ferroptosis and apoptosis by downregulating PLAGL2 and repressing HIF-1α/VEGF signaling pathway in newborn alveolar typeII epithelial cell

Hyperoxia exposure induces ferroptosis and apoptosis by downregulating PLAGL2 and repressing HIF-1α/VEGF signaling pathway in newborn alveolar typeII epithelial cell

Backgroud Bronchopulmonary dysplasia (BPD) is one of the most important complications plaguing neonates and can lead to a variety of sequelae. the ability of the HIF-1α/VEGF signaling pathway to promote angiogenesis has an important role in neonatal lung development.Method Newborn rats were exposed...

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Bibliographic Details
Main Authors: Yuting Zhu, Hongmei Hou, Yawen Li, Yanyu Zhang, Yuanyuan Fang, Si Chen, Le Zhang, Weilai Jin, Yahui Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Redox Report
Subjects:
Bronchopulmonary dysplasia (BPD)
PLAGL 2
HIF-1α/VEGF pathway
lung injury
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2024.2387465
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https://www.tandfonline.com/doi/10.1080/13510002.2024.2387465

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