High cyclic GMP-AMP synthase and stimulator of interferon genes in cholangiocarcinoma suggest their potential as targets for treatment

High cyclic GMP-AMP synthase and stimulator of interferon genes in cholangiocarcinoma suggest their potential as targets for treatment

Background Cancer remains the leading cause of death worldwide. Chromosomal instability (CIN) is one hallmark of cancer. Micronuclei (MN) is an observable outcome of CIN. The role of cytosolic MNs or DNAs in activating an immune response via a cyclic guanosine monophosphate–adenosine monophosphate (...

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Main Authors: Han Ni Zin Myint, Paksiree Saranaruk, Natnicha Paungpan, Sakda Waraasawapati, Chawalit Pairojkul, Saowaluk Saisomboon, Nutsara Settha, Jatuporn Pattanachot, Seiji Okada, Wunchana Seubwai, Amnat Kitkhuandee, Kanlayanee Sawanyawisuth, Kulthida Vaeteewoottacharn
Format: Article
Language:English
Published: PeerJ Inc. 2025-08-01
Series:PeerJ
Subjects:
Cholangiocarcinoma
Micronuclei
cGAS
STING
NF-κB p65
RELA
Online Access:https://peerj.com/articles/19800.pdf
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