Nanoparticles loaded with the DNA methyltransferase inhibitor SGI-1027 decrease murine atherosclerosis and inflammation in cultured human macrophages

Nanoparticles loaded with the DNA methyltransferase inhibitor SGI-1027 decrease murine atherosclerosis and inflammation in cultured human macrophages

Aim: The DNA of the atheroma is hypermethylated relative to adjacent healthy vascular tissue. A significant portion of hypermethylated loci in the atheroma DNA map to genes related to macrophage function. Reversing macrophage DNA methylation to physiological levels by targeting DNA methyltransferase...

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Main Authors: Ana Cristina Márquez-Sánchez, Alejandro Manzanares-Guzmán, Ramón Carriles-Jaimes, Lino Sánchez-Segura, Dannia Colín-Castelán, Dan Kamen, Ekaterina K. Koltsova, Agustino Martínez-Antonio, Dalia Rodríguez-Ríos, Gloria del Carmen Romo-Morales, Gertrud Lund, Silvio Zaina
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2024-04-01
Series:Exploration of Cardiology
Subjects:
nanoparticle
dna methylation inhibitor
atherosclerosis
inflammation
Online Access:https://www.explorationpub.com/uploads/Article/A101221/101221.pdf
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