RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α

RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α

Abstract Defective DNA repair and metabolic rewiring are highly intertwined in promoting the development and progression of cancer. However, the molecular players at their interface remain poorly understood. Here we show that an RNF20-HIF1α axis links the DNA damage response and metabolic reprogramm...

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Main Authors: Hao Liu, Yongqin Tang, Anshu Singh, Joaquim Vong, Julio Cordero, Arthur Mathes, Rui Gao, Yanhan Jia, Boyan K. Garvalov, Till Acker, Gernot Poschet, Rüdiger Hell, Marc A. Schneider, Joerg Heineke, Thomas Wieland, Guillermo Barreto, Adelheid Cerwenka, Michael Potente, Sofia-Iris Bibli, Rajkumar Savai, Gergana Dobreva
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60223-4
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https://doi.org/10.1038/s41467-025-60223-4

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