Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation

Abstract The microtubule (MT) association of protein Tau is decreased upon phosphorylation. Increased levels of phosphorylated Tau in the cytosol pose the risk of pathological aggregation, as observed in neurodegenerative diseases. We show that binding of 14-3-3ζ enhances cytosolic Tau solubility by...

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Main Authors: Janine Hochmair, Maxime C. M. van den Oetelaar, Leandre Ravatt, Lisa Diez, Lenne J. M. Lemmens, Renata Ponce-Lina, Rithika Sankar, Maximilian Franck, Gesa Nolte, Ekaterina Semenova, Satabdee Mohapatra, Christian Ottmann, Luc Brunsveld, Susanne Wegmann
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08548-0
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https://doi.org/10.1038/s42003-025-08548-0

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