Epileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome

Epileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome

IntroductionGlucose Transporter 1-Deficiency Syndrome (GLUT1-DS) is a rare genetic disorder caused by mutations in the gene encoding for GLUT1 and characterized by impaired glucose uptake in the brain. This leads to brain hypometabolism and the development of symptoms that include epilepsy, motor dy...

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Bibliographic Details
Main Authors: Y. Müller, L. Lengacher, F. Friscourt, C. Quairiaux, L. Stoppini, P. J. Magistretti, S. Lengacher, C. Finsterwald
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Neuroscience
Subjects:
GLUT1-DS
epilepsy
brain organoid
astrocyte
glucose
brain energy metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1498801/full
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https://www.frontiersin.org/articles/10.3389/fnins.2024.1498801/full

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