TGF-β superfamily-induced transcriptional activation pathways establish the RAD52-dependent ALT machinery during malignant transformation of MPNSTs

TGF-β superfamily-induced transcriptional activation pathways establish the RAD52-dependent ALT machinery during malignant transformation of MPNSTs

Abstract To study telomere maintenance mechanism (TMM) activation during malignant transformation, we compared neurofibroma (NF) and malignant peripheral nerve sheath tumor (MPNST) in the same patient with type-1 neurofibromatosis (NF1), a total of 20 NF-MPNST pairs in 20 NF1 patients. These compari...

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Bibliographic Details
Main Authors: Eunji Choi, Jungwoo Lee, HyoJu Kim, Young-Joon Kim, Seung Hyun Kim
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Telomere
TGF-β superfamily
PAX
SOX
Transcriptional activation
RAD52-dependent ALT
Online Access:https://doi.org/10.1038/s41598-024-76732-z
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https://doi.org/10.1038/s41598-024-76732-z

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