Neuro-Inflammatory and Behavioral Changes Are Selectively Reversed by <i>Sceletium tortuosum</i> (Zembrin<sup>®</sup>) and Mesembrine in Male Rats Subjected to Unpredictable Chronic Mild Stress

Neuro-Inflammatory and Behavioral Changes Are Selectively Reversed by <i>Sceletium tortuosum</i> (Zembrin<sup>®</sup>) and Mesembrine in Male Rats Subjected to Unpredictable Chronic Mild Stress

<i>Sceletium tortuosum</i> (ST) induces antidepressant and anxiolytic effects, purportedly by monoamine regulation, anti-inflammatory and antioxidant properties, and phosphodiesterase 4 (PDE4) inhibition. These multimodal actions have not been demonstrated in an animal model of major dep...

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Bibliographic Details
Main Authors: Johané Gericke, Stephan F. Steyn, Francois P. Viljoen, Brian H. Harvey
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
anhedonia
antioxidant
anxious depression
hyperarousal
inflammation
phosphodiesterase 4B
Online Access:https://www.mdpi.com/2073-4409/14/13/1029
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