Chemometric-assisted UV spectrophotometric methods for determination of miconazole nitrate and lidocaine hydrochloride along with potential impurity and dosage from preservatives

Abstract Three accurate, simple, and precise chemometric techniques, principal component regression (PCR), partial least squares (PLS), and backward interval partial least squares (biPLS) were used to resolve the severely overlapped UV spectra of miconazole nitrate (MIC) and Lidocaine hydrochloride...

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Bibliographic Details
Main Authors: Esraa S. Ashour, Ghada M. El-Sayed, Maha A. Hegazy, Nermine S. Ghoniem
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Chemistry
Subjects:
Online Access:https://doi.org/10.1186/s13065-025-01447-9
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