A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease

A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex–associated Alzheimer's disease

Abstract Introduction Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis. Methods Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age‐ and sex‐matched controls,...

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Bibliographic Details
Main Authors: Karin Lopatko Lindman, Bodil Weidung, Jan Olsson, Maria Josefsson, Eloise Kok, Anders Johansson, Sture Eriksson, Göran Hallmans, Fredrik Elgh, Hugo Lövheim
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Herpes simplex
HSV
Apolipoprotein E4
APOEε4
Alzheimer's disease
Dementia
Online Access:https://doi.org/10.1016/j.trci.2019.09.014
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https://doi.org/10.1016/j.trci.2019.09.014

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