Multi-omics study reveals gut microbiota dysbiosis and tryptophan metabolism alterations in GH-PitNET progression

Multi-omics study reveals gut microbiota dysbiosis and tryptophan metabolism alterations in GH-PitNET progression

Abstract Growth hormone-secreting pituitary neuroendocrine tumors (GH-PitNETs) arise from the anterior pituitary gland and constitute 20–30% of all PitNETs, representing a significant subset of functional pituitary tumors. Despite their prevalence, the precise mechanisms underlying the development o...

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Bibliographic Details
Main Authors: Jifang Liu, Zhang Ye, Yi Zhang, Shen You, Siqi Sun, Lin Lu, Wan Su, Jie Liu, Jun Pu, Hui Pan, Huijuan Zhu, Kan Deng, Yong Yao, Xiaomin Hu, Shuyang Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
GH-PitNETs
Gut microbiota
Indole-3-acetic acid
Online Access:https://doi.org/10.1038/s41598-025-07812-x
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https://doi.org/10.1038/s41598-025-07812-x

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