Irisin attenuates SARS-CoV-2 entry into cells and cell damage in 2D and 3D cultures of human subcutaneous adipocytes

Irisin attenuates SARS-CoV-2 entry into cells and cell damage in 2D and 3D cultures of human subcutaneous adipocytes

Introduction: COVID-19 is associated with an inflammatory pathophysiology and, when associated with chronic diseases, can trigger severe infection and increase death risk. Irisin, a hormone produced by skeletal muscle during physical activity, has demonstrated therapeutic effects against metabolic d...

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Main Authors: Maria Teresa De Sibio, Ester Mariane Vieira, Paula Barreto Da Rocha, Miriane De Oliveira, Regiane Marques Castro Olímpio, Vinícius Vigliazzi Peghinelli, Lucas Solla Mathias, Helena Paim Tilli, Bianca Mariani Gonçalves, Igor Deprá, Maria Beatriz Bravin, Mariana Menezes Lourenço, Giovanna Bonatto Luca, Matheus de Souza Marino, Pedro Henrique Soares Kossooski, Camila Renata Corrêa, Marna Eliana Sakalem, Cormarie Fernández Pulido, Célia Regina Nogueira
Format: Article
Language:English
Published: Bioscientifica 2025-08-01
Series:Endocrine Connections
Subjects:
irisin
sars-cov-2
2d and 3d cell culture
human adipocytes
Online Access:https://ec.bioscientifica.com/view/journals/ec/14/8/EC-25-0046.xml
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