CoreTIA: a modular, statistically robust transduction inhibition assay for AAV neutralization

CoreTIA: a modular, statistically robust transduction inhibition assay for AAV neutralization

Adeno-associated virus (AAV) gene therapy is often limited by pre-existing neutralizing antibodies (NAbs), yet current assays for NAb detection lack standardization and rarely quantify uncertainty, complicating cross-study comparisons. We present coreTIA (core Transduction Inhibition Assay), a compr...

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Bibliographic Details
Main Authors: Beatrix Kovács, Fanni Somogyi, Viktória Szabó, Zoltán Zsolt Nagy, István Hernádi, Ferenc Mátyás, Wim Vanduffel, Zsuzsanna Szemlaky, Balázs Rózsa, István Ulbert, Dániel Hillier
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
AAV neutralizing antibodies
gene therapy immunogenicity
neutralizing antibody titer
Bayesian dose-response modeling
ND50 quantification with uncertainty
AAV serotype optimization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1623848/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1623848/full

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