Glycosylated Delphinidins Decrease Chemoresistance to Temozolomide by Regulating NF-κB/MGMT Signaling in Glioblastoma

Glycosylated Delphinidins Decrease Chemoresistance to Temozolomide by Regulating NF-κB/MGMT Signaling in Glioblastoma

Glioblastoma (GB) is a highly malignant brain tumor with a poor prognosis, with a median survival of only 14.6 months despite aggressive treatments. Resistance to chemotherapy, particularly temozolomide (TMZ), is a significant challenge. The DNA repair enzyme MGMT and glioblastoma stem cells (GSCs)...

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Main Authors: Diego Carrillo-Beltrán, Yessica Nahuelpan, Constanza Cuevas, Karen Fabres, Pamela Silva, Jimena Zubieta, Giovanna Navarro, Juan P. Muñoz, María A. Gleisner, Flavio Salazar-Onfray, Noemi Garcia-Romero, Angel Ayuso-Sacido, Rody San Martin, Claudia Quezada-Monrás
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
delphinidins
temozolomide
glioblastoma
GSCs
chemoresistance
NF-κB
Online Access:https://www.mdpi.com/2073-4409/14/3/179
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