Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content
An increasing number of biological activities presented by medicinal plants has been investigated over the years, and they are used in the search for new substances with lower side effects. Eugenia uniflora L. and Eugenia malaccensis L. (Myrtaceae) have many folk uses in various countries. This curr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/125027 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565129672130560 |
|---|---|
| author | Evellyne de Oliveira Figueirôa Luís Cláudio Nascimento da Silva Cristiane Moutinho Lagos de Melo Juliana Kelle de Andrade Lemoine Neves Nicácio Henrique da Silva Valéria Rêgo Alves Pereira Maria Tereza dos Santos Correia |
| author_facet | Evellyne de Oliveira Figueirôa Luís Cláudio Nascimento da Silva Cristiane Moutinho Lagos de Melo Juliana Kelle de Andrade Lemoine Neves Nicácio Henrique da Silva Valéria Rêgo Alves Pereira Maria Tereza dos Santos Correia |
| author_sort | Evellyne de Oliveira Figueirôa |
| collection | DOAJ |
| description | An increasing number of biological activities presented by medicinal plants has been investigated over the years, and they are used in the search for new substances with lower side effects. Eugenia uniflora L. and Eugenia malaccensis L. (Myrtaceae) have many folk uses in various countries. This current study was designed to quantify the polyphenols and flavonoids contents and evaluate the immunomodulatory, antioxidant, and cytotoxic potentials of fractions from E. uniflora L. and E. malaccensis L. It was observed that the polyphenol content was higher in ethyl acetate fractions. These fractions have high antioxidant potential. E. malaccensis L. seeds showed the largest DPPH radical scavenger capacity (EC50=22.62). The fractions of E. malaccensis L. leaves showed lower antioxidant capacity. The samples did not alter the profile of proinflammatory cytokines and nitric oxide release. The results indicate that species of the family Myrtaceae are rich in compounds with antioxidant capacity, which can help reduce the inflammatory response. |
| format | Article |
| id | doaj-art-d0adc521179848aa8e63f02076d254e0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d0adc521179848aa8e63f02076d254e02025-02-03T01:09:28ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/125027125027Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid ContentEvellyne de Oliveira Figueirôa0Luís Cláudio Nascimento da Silva1Cristiane Moutinho Lagos de Melo2Juliana Kelle de Andrade Lemoine Neves3Nicácio Henrique da Silva4Valéria Rêgo Alves Pereira5Maria Tereza dos Santos Correia6Laboratório de Glicoproteínas, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Professor Moraes Rêgo s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilLaboratório de Glicoproteínas, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Professor Moraes Rêgo s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilLaboratório de Imunoparasitologia, Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz/PE, Avenida Professor Moraes Rego s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilLaboratório de Imunoparasitologia, Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz/PE, Avenida Professor Moraes Rego s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilLaboratório de Produtos Naturais, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Professor Moraes Rêgo s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilLaboratório de Imunoparasitologia, Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz/PE, Avenida Professor Moraes Rego s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilLaboratório de Glicoproteínas, Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Avenida Professor Moraes Rêgo s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilAn increasing number of biological activities presented by medicinal plants has been investigated over the years, and they are used in the search for new substances with lower side effects. Eugenia uniflora L. and Eugenia malaccensis L. (Myrtaceae) have many folk uses in various countries. This current study was designed to quantify the polyphenols and flavonoids contents and evaluate the immunomodulatory, antioxidant, and cytotoxic potentials of fractions from E. uniflora L. and E. malaccensis L. It was observed that the polyphenol content was higher in ethyl acetate fractions. These fractions have high antioxidant potential. E. malaccensis L. seeds showed the largest DPPH radical scavenger capacity (EC50=22.62). The fractions of E. malaccensis L. leaves showed lower antioxidant capacity. The samples did not alter the profile of proinflammatory cytokines and nitric oxide release. The results indicate that species of the family Myrtaceae are rich in compounds with antioxidant capacity, which can help reduce the inflammatory response.http://dx.doi.org/10.1155/2013/125027 |
| spellingShingle | Evellyne de Oliveira Figueirôa Luís Cláudio Nascimento da Silva Cristiane Moutinho Lagos de Melo Juliana Kelle de Andrade Lemoine Neves Nicácio Henrique da Silva Valéria Rêgo Alves Pereira Maria Tereza dos Santos Correia Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content The Scientific World Journal |
| title | Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content |
| title_full | Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content |
| title_fullStr | Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content |
| title_full_unstemmed | Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content |
| title_short | Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content |
| title_sort | evaluation of antioxidant immunomodulatory and cytotoxic action of fractions from eugenia uniflora l and eugenia malaccensis l correlation with polyphenol and flavanoid content |
| url | http://dx.doi.org/10.1155/2013/125027 |
| work_keys_str_mv | AT evellynedeoliveirafigueiroa evaluationofantioxidantimmunomodulatoryandcytotoxicactionoffractionsfromeugeniaunifloralandeugeniamalaccensislcorrelationwithpolyphenolandflavanoidcontent AT luisclaudionascimentodasilva evaluationofantioxidantimmunomodulatoryandcytotoxicactionoffractionsfromeugeniaunifloralandeugeniamalaccensislcorrelationwithpolyphenolandflavanoidcontent AT cristianemoutinholagosdemelo evaluationofantioxidantimmunomodulatoryandcytotoxicactionoffractionsfromeugeniaunifloralandeugeniamalaccensislcorrelationwithpolyphenolandflavanoidcontent AT julianakelledeandradelemoineneves evaluationofantioxidantimmunomodulatoryandcytotoxicactionoffractionsfromeugeniaunifloralandeugeniamalaccensislcorrelationwithpolyphenolandflavanoidcontent AT nicaciohenriquedasilva evaluationofantioxidantimmunomodulatoryandcytotoxicactionoffractionsfromeugeniaunifloralandeugeniamalaccensislcorrelationwithpolyphenolandflavanoidcontent AT valeriaregoalvespereira evaluationofantioxidantimmunomodulatoryandcytotoxicactionoffractionsfromeugeniaunifloralandeugeniamalaccensislcorrelationwithpolyphenolandflavanoidcontent AT mariaterezadossantoscorreia evaluationofantioxidantimmunomodulatoryandcytotoxicactionoffractionsfromeugeniaunifloralandeugeniamalaccensislcorrelationwithpolyphenolandflavanoidcontent |