EPS8L2 drives colorectal cancer cell proliferation and migration via YBX1-dependent activation of G3BP2 transcription

Abstract Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, characterized by molecular heterogeneity and limited therapeutic options. Here, we identified EPS8L2 as a novel driver of colorectal tumorigenesis. EPS8L2 is significantly upregulated in CRC tissues and n...

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Bibliographic Details
Main Authors: Yimeng Duan, Peixian Li, Yanmei Yang, Guanghua Wu, Hao Xing, Hong Chen, Liangbo Zhao, Lei Liu, Xiao Sun, Shuiling Jin, Luyun He, Benyu Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07929-x
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