Impact of Renin-Angiotensin System Inhibitors on Disease Characteristics in Patients with Localized Prostate Cancer Treated with Radical Prostatectomy: A European Association of Urology Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study

Impact of Renin-Angiotensin System Inhibitors on Disease Characteristics in Patients with Localized Prostate Cancer Treated with Radical Prostatectomy: A European Association of Urology Young Academic Urologists Prostate Cancer Working Group Multi-institutional Study

Background and objective: Collagen biosynthesis is intricately involved in the development and progression of solid tumors. Renin-angiotensin system inhibitors (RASi) impede TGF-β-mediated collagen synthesis in tumors by hindering activation of the angiotensin receptor. Our aim was to investigate a...

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Main Authors: Nastasiia Artamonova, Mona Kafka, Laura Faiss, David Avetisyan, Ignacio Puche Sanz, Giulia La Bombarda, Gennaio Iacono, Fabio Zattoni, Eberhard Steiner, Caroline D’Elia, Armin Pycha, Michael Ladurner, Samed Jagodic, Giorgio Gandaglia, Isabel Heidegger
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:European Urology Open Science
Subjects:
Cancer aggressiveness
Prostate cancer
Renin-angiotensin system inhibitor
Real-world evidence
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168324009248
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