RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting m6A methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenotype

RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting m6A methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenotype

Abstract Background Triple-negative breast cancer (TNBC) is one of the breast cancer subtypes with a poor prognosis, and the current main treatment modalities include surgical resection and adjuvant chemotherapy. However, the development of drug resistance in tumor cells to chemotherapeutic agents p...

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Bibliographic Details
Main Authors: Jinkun Fu, Chao Wei, Yijian Chen, Xiaoming He, Kun Zhang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Hereditas
Subjects:
Triple-negative breast cancer
PTX-resistant
TNFSF9
RBM15
M2 polarization
Online Access:https://doi.org/10.1186/s41065-025-00534-0
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https://doi.org/10.1186/s41065-025-00534-0

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