The Synthesis and Biological Evaluation of a Novel Pleuromutilin Derivative Containing a 4-Fluorophenyl Group Targeting MRSA

The Synthesis and Biological Evaluation of a Novel Pleuromutilin Derivative Containing a 4-Fluorophenyl Group Targeting MRSA

The pleuromutilin derivative, the compound PL-W, was synthesized by introducing a 4-fluorophenyl group at the C21 position and selected for comprehensive antibacterial evaluation. PL-W demonstrated notable antibacterial activity against methicillin-resistant <i>Staphylococcus aureus</i>...

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Bibliographic Details
Main Authors: Yongfei Wang, Yi Zhao, Haiting Wang, Bo Liu, Shuangyi Zhang, Yuan Liu, Ruinan Li, Tao Zhang, Surong Hasi, Wei Mao
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
pleuromutilin derivative
methicillin-resistant <i>Staphylococcus aureus</i>
antibacterial activity
molecular docking
Online Access:https://www.mdpi.com/1420-3049/30/11/2366
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