A glyco-engineering approach for site-specific conjugation to Fab glycans

A glyco-engineering approach for site-specific conjugation to Fab glycans

Effective processes for synthesizing antibody-drug conjugates (ADCs) require: 1) site-specific incorporation of the payload to avoid interference with binding to the target epitope, 2) optimal drug/antibody ratio to achieve sufficient potency while avoiding aggregation or solubility problems, and 3)...

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Main Authors: Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Actinobacillus
antibody
cetuximab
drug conjugate
Fab glycan
sialyltransferase
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2149057
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https://www.tandfonline.com/doi/10.1080/19420862.2022.2149057

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