Ectopic expression of GDF15 in cancer-associated fibroblasts enhances melanoma immunosuppression via the GFRAL/RET cascade

Ectopic expression of GDF15 in cancer-associated fibroblasts enhances melanoma immunosuppression via the GFRAL/RET cascade

Background A key aspect of tumor biology is the involvement of cancer-associated fibroblasts (CAFs) in shaping the immunosuppressive microenvironment. However, the dynamic and complex key roles of CAFs in the melanoma immune microenvironment have not been elucidated.Methods The CAFs landscape in mel...

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Main Authors: Zhiheng Lin, Li Lin, Yisheng Chen, Yantao Ding, Xiaojing Wang, Zhiwen Luo, Zhenzhen Zhao, Zhijie Zhao, Huabao Cai, Wenyang Nie, Fu Zhao
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e011036.full
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