Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegans
Objective: To investigate the anti-aging effect of camel milk immunoglobulin G (IgG) at different concentrations (0.25, 0.5, 1, 2, and 4 mg/mL) on the model organism Caenorhabditis elegans. Methods: The anti-aging activity of camel milk IgG was evaluated by analyzing the lifespan, reproductive capac...
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China Food Publishing Company
2024-11-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-22-013.pdf |
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| author | ZHAO Xiaomeng, GONG Chunmiao, CHEN Shuxing, WANG Xiaonan, LI Qianwen |
| author_facet | ZHAO Xiaomeng, GONG Chunmiao, CHEN Shuxing, WANG Xiaonan, LI Qianwen |
| author_sort | ZHAO Xiaomeng, GONG Chunmiao, CHEN Shuxing, WANG Xiaonan, LI Qianwen |
| collection | DOAJ |
| description | Objective: To investigate the anti-aging effect of camel milk immunoglobulin G (IgG) at different concentrations (0.25, 0.5, 1, 2, and 4 mg/mL) on the model organism Caenorhabditis elegans. Methods: The anti-aging activity of camel milk IgG was evaluated by analyzing the lifespan, reproductive capacity, locomotory capacity, stress resistance, and lipofuscin level of C. elegans. Results: Compared with the control group, the concentration of IgG in camel milk was safe, which damaged neither the reproductive nor locomotory capacity of C. elegans. Feeding of camel milk IgG at concentrations of 1, 2, and 4 mg/mL significantly prolonged the average lifespan of C. elegans, and at 0.5 and 4 mg/mL significantly increased the swallowing frequency (P < 0.05). Feeding of camel milk IgG at 0.25, 0.5 and 1 mg/mL significantly improved the heat stress resistance, and significantly prolonged the average lifespan of C. elegans (P < 0.05). Feeding of camel milk IgG at 1 and 4 mg/mL significantly increased the oxidative stress resistance of C. elegans (P < 0.05), and lipofuscin deposition was significantly decreased after 14-day feeding of camel milk IgG at 0.5 and 2 mg/mL (P < 0.05). Conclusion: Feeding a certain concentration of camel milk IgG has an anti-aging effect on C. elegans. |
| format | Article |
| id | doaj-art-d0765378f5534cf2828a2caa60258a2c |
| institution | OA Journals |
| issn | 1002-6630 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-d0765378f5534cf2828a2caa60258a2c2025-08-20T02:27:43ZengChina Food Publishing CompanyShipin Kexue1002-66302024-11-01452211211710.7506/spkx1002-6630-20240411-097Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegansZHAO Xiaomeng, GONG Chunmiao, CHEN Shuxing, WANG Xiaonan, LI Qianwen0(1. College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China; 2. Food Laboratory of Zhongyuan, Luohe 462333, China)Objective: To investigate the anti-aging effect of camel milk immunoglobulin G (IgG) at different concentrations (0.25, 0.5, 1, 2, and 4 mg/mL) on the model organism Caenorhabditis elegans. Methods: The anti-aging activity of camel milk IgG was evaluated by analyzing the lifespan, reproductive capacity, locomotory capacity, stress resistance, and lipofuscin level of C. elegans. Results: Compared with the control group, the concentration of IgG in camel milk was safe, which damaged neither the reproductive nor locomotory capacity of C. elegans. Feeding of camel milk IgG at concentrations of 1, 2, and 4 mg/mL significantly prolonged the average lifespan of C. elegans, and at 0.5 and 4 mg/mL significantly increased the swallowing frequency (P < 0.05). Feeding of camel milk IgG at 0.25, 0.5 and 1 mg/mL significantly improved the heat stress resistance, and significantly prolonged the average lifespan of C. elegans (P < 0.05). Feeding of camel milk IgG at 1 and 4 mg/mL significantly increased the oxidative stress resistance of C. elegans (P < 0.05), and lipofuscin deposition was significantly decreased after 14-day feeding of camel milk IgG at 0.5 and 2 mg/mL (P < 0.05). Conclusion: Feeding a certain concentration of camel milk IgG has an anti-aging effect on C. elegans.https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-22-013.pdfcamel milk immunoglobulin g; caenorhabditis elegans; anti-aging |
| spellingShingle | ZHAO Xiaomeng, GONG Chunmiao, CHEN Shuxing, WANG Xiaonan, LI Qianwen Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegans Shipin Kexue camel milk immunoglobulin g; caenorhabditis elegans; anti-aging |
| title | Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegans |
| title_full | Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegans |
| title_fullStr | Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegans |
| title_full_unstemmed | Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegans |
| title_short | Anti-aging Effect of Camel Milk Immunoglobulin G on Caenorhabditis elegans |
| title_sort | anti aging effect of camel milk immunoglobulin g on caenorhabditis elegans |
| topic | camel milk immunoglobulin g; caenorhabditis elegans; anti-aging |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-22-013.pdf |
| work_keys_str_mv | AT zhaoxiaomenggongchunmiaochenshuxingwangxiaonanliqianwen antiagingeffectofcamelmilkimmunoglobulingoncaenorhabditiselegans |