IL-1β promotes glutamate excitotoxicity: indications for the link between inflammatory and synaptic vesicle cycle in Ménière’s disease

Abstract Ménière’s disease (MD) is a complex inner ear disorder characterized by a range of symptoms, with its pathogenesis linked to immune-related mechanisms. Our previous research demonstrated that IL-1β maturation and release can trigger cell pyroptosis, exacerbating the severity of the endolymp...

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Main Authors: Na Zhang, Yongdong Song, Hanyue Wang, Xiaofei Li, Yafeng Lyu, Jiahui Liu, Yurong Mu, Yan Wang, Yao Lu, Guorong Li, Zhaomin Fan, Haibo Wang, Daogong Zhang, Na Li
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02246-2
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